# PTMA

Source: https://onco.cc/targets/ptma/  
OnCo record `ptma` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.

## Summary

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Mixed Germ Cell Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: prothymosin alpha; Prothymosin alpha
- Tags: cancer-genes-wave
- Symbol: PTMA
- Class: oncogene
- Biology: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Location: Nucleus (UniProt). Locus 2q37.1 (HGNC).
- Where found: Testicular germ cell tumours: IntOGen driver in 1 cohort (MGCT)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9623: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9623
- UniProt P06454: https://www.uniprot.org/uniprotkb/P06454/entry
- NCBI Gene 5757: https://www.ncbi.nlm.nih.gov/gene/5757
- Ensembl ENSG00000187514: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187514

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Testicular germ cell tumours](https://onco.cc/cancers/testicular/)

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JSON: https://onco.cc/api/v1/entities/ptma.json