# PTP4A3

Source: https://onco.cc/targets/ptp4a3/  
OnCo record `ptp4a3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase 4A3; Protein tyrosine phosphatase type IVA 3; PRL-3; PRL-R; PRL3
- Tags: cancer-genes-wave
- Symbol: PTP4A3
- Class: enzyme
- Biology: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II. Location: Cell membrane; Early endosome (UniProt). Locus 8q24.3 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9636: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9636
- UniProt O75365: https://www.uniprot.org/uniprotkb/O75365/entry
- NCBI Gene 11156: https://www.ncbi.nlm.nih.gov/gene/11156
- Ensembl ENSG00000184489: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184489

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- trials: [A Study to Assess Safety and Efficacy of PRL3-Zumab in Patients With Solid Tumors](https://onco.cc/trials/nct04452955/), [Phase II/III Trial of PRL3-Zumab in Advanced Solid Tumor Patients](https://onco.cc/trials/nct07290088/), [PRL3-Zumab in Patients With Advanced Solid Tumors](https://onco.cc/trials/nct07541001/)

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JSON: https://onco.cc/api/v1/entities/ptp4a3.json