# PTPN12

Source: https://onco.cc/targets/ptpn12/  
OnCo record `ptpn12` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.

## Summary

Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Crizotinib and Sunitinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase non-receptor type 12; Tyrosine-protein phosphatase non-receptor type 12; PTPG1; PTP-PEST
- Tags: cancer-genes-wave
- Symbol: PTPN12
- Class: enzyme
- Biology: Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. Location: Cytoplasm; Cell junction, focal adhesion; Cell projection, podosome (UniProt). Locus 7q11.23 (HGNC).
- Where found: Triple-negative breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9645: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9645
- UniProt Q05209: https://www.uniprot.org/uniprotkb/Q05209/entry
- NCBI Gene 5782: https://www.ncbi.nlm.nih.gov/gene/5782
- Ensembl ENSG00000127947: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127947

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Triple-negative breast cancer (TNBC)](https://onco.cc/cancers/tnbc/)

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JSON: https://onco.cc/api/v1/entities/ptpn12.json