# PTPN13

Source: https://onco.cc/targets/ptpn13/  
OnCo record `ptpn13` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTPN13 (Tyrosine-protein phosphatase non-receptor type 13) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma, Endometrial cancer and 3 more.

## Summary

Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.86). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreas, Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase non-receptor type 13; Tyrosine-protein phosphatase non-receptor type 13; PTP1E; PTP-BAS; PTPL1; PTP-BL
- Tags: cancer-genes-wave
- Symbol: PTPN13
- Class: enzyme
- Biology: Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2. Location: Cytoplasm, cytoskeleton; Nucleus; Cell projection, lamellipodium (UniProt). Locus 4q21.3 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PANCREAS); Endometrial cancer: IntOGen driver in 1 cohort (UCEC); Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254); Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9646: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9646
- UniProt Q12923: https://www.uniprot.org/uniprotkb/Q12923/entry
- NCBI Gene 5783: https://www.ncbi.nlm.nih.gov/gene/5783
- Ensembl ENSG00000163629: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163629

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Melanoma](https://onco.cc/cancers/melanoma/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ptpn13.json