# PTPN14

Source: https://onco.cc/targets/ptpn14/  
OnCo record `ptpn14` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTPN14 (Tyrosine-protein phosphatase non-receptor type 14) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.

## Summary

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.94, animal model 0.34, genetic association 0.60, somatic mutation 0.61). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Basal Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase non-receptor type 14; Tyrosine-protein phosphatase non-receptor type 14; PTPD2
- Tags: cancer-genes-wave
- Symbol: PTPN14
- Class: tumor-suppressor
- Biology: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumour suppressor. Location: Cytoplasm; Cytoplasm, cytoskeleton; Nucleus (UniProt). Locus 1q32.3-q41 (HGNC).
- Where found: Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9647: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9647
- UniProt Q15678: https://www.uniprot.org/uniprotkb/Q15678/entry
- NCBI Gene 5784: https://www.ncbi.nlm.nih.gov/gene/5784
- Ensembl ENSG00000152104: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000152104

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/)

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JSON: https://onco.cc/api/v1/entities/ptpn14.json