# PTPN22

Source: https://onco.cc/targets/ptpn22/  
OnCo record `ptpn22` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTPN22 (Tyrosine-protein phosphatase non-receptor type 22) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Acts as a negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.74, animal model 0.50, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase non-receptor type 22; Tyrosine-protein phosphatase non-receptor type 22; Lyp; Lyp1; Lyp2; PTPN8
- Tags: cancer-genes-wave
- Symbol: PTPN22
- Class: enzyme
- Biology: Acts as a negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Location: Cytoplasm (UniProt). Locus 1p13.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9652: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9652
- UniProt Q9Y2R2: https://www.uniprot.org/uniprotkb/Q9Y2R2/entry
- NCBI Gene 26191: https://www.ncbi.nlm.nih.gov/gene/26191
- Ensembl ENSG00000134242: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134242

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ptpn22.json