# PTPRC

Source: https://onco.cc/targets/ptprc/  
OnCo record `ptprc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTPRC (Receptor-type tyrosine-protein phosphatase C) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Anal cancer, Hepatocellular carcinoma, Skin cancer and 5 more.

## Summary

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.99, animal model 0.46, genetic association 0.18, somatic mutation 0.85). IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Anal Squamous Cell Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Hepatocellular Carcinoma, Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase receptor type C; Receptor-type tyrosine-protein phosphatase C; T200; GP180; LY5; B220; CD45R; CD45
- Tags: cancer-genes-wave
- Symbol: PTPRC
- Class: enzyme
- Biology: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognises Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. Location: Cell membrane; Membrane raft; Synapse (UniProt). Locus 1q31.3-q32.1 (HGNC).
- Where found: Anal cancer: IntOGen driver in 1 cohort (ANSC); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575); Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9666: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9666
- UniProt P08575: https://www.uniprot.org/uniprotkb/P08575/entry
- NCBI Gene 5788: https://www.ncbi.nlm.nih.gov/gene/5788
- Ensembl ENSG00000081237: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000081237

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Anal cancer (squamous cell carcinoma)](https://onco.cc/cancers/anal/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ptprc.json