# PTPRF

Source: https://onco.cc/targets/ptprf/  
OnCo record `ptprf` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

PTPRF (Receptor-type tyrosine-protein phosphatase F) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Erlotinib Hydrochloride.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: protein tyrosine phosphatase receptor type F; Receptor-type tyrosine-protein phosphatase F
- Tags: cancer-genes-wave
- Symbol: PTPRF
- Class: enzyme
- Biology: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Location: Membrane (UniProt). Locus 1p34.2 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9670: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9670
- UniProt P10586: https://www.uniprot.org/uniprotkb/P10586/entry
- NCBI Gene 5792: https://www.ncbi.nlm.nih.gov/gene/5792
- Ensembl ENSG00000142949: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142949

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/ptprf.json