# QUAIL-100

Source: https://onco.cc/drugs/quail-100/  
OnCo record `quail-100` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

QUAIL-100 is an experimental live bacterial therapy from Laguna Biotherapeutics, in phase 1 trials for acute leukaemia and myelodysplastic syndrome.

## Summary

QUAIL-100 is a live bacterial therapy (attenuated) from Laguna Biotherapeutics. A live, attenuated bacterial therapeutic from Laguna's QUAIL platform, which uses highly attenuated microbes designed to activate and expand the body's own innate T cells. Its furthest stage is phase 1, for acute leukaemia and myelodysplastic syndrome. ClinicalTrials.gov registers it in one study linked below. First-in-human NCT07573111 recruiting (registry, checked 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: QUAIL-100
- Modality: Live bacterial therapy (attenuated)
- Mechanism: A live, attenuated bacterial therapeutic from Laguna's QUAIL platform, which uses highly attenuated microbes designed to activate and expand the body's own innate T cells.

## Sources

- Laguna Biotherapeutics: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07573111
- Laguna Biotherapeutics: lagunabio.com: https://lagunabio.com/
- ClinicalTrials.gov: trials of QUAIL-100: https://clinicaltrials.gov/search?intr=QUAIL-100

## Connected records

- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)
- companies: [Laguna Biotherapeutics](https://onco.cc/companies/laguna-biotherapeutics/)
- trials: [Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation](https://onco.cc/trials/nct07573111/)

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