# RABL3

Source: https://onco.cc/targets/rabl3/  
OnCo record `rabl3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RABL3 (Rab-like protein 3) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.67, genetic literature 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RAB, member of RAS oncogene family like 3; Rab-like protein 3; MGC23920
- Tags: cancer-genes-wave
- Symbol: RABL3
- Class: enzyme
- Biology: Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development. Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Golgi apparatus (UniProt). Locus 3q13.33 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18072: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18072
- UniProt Q5HYI8: https://www.uniprot.org/uniprotkb/Q5HYI8/entry
- NCBI Gene 285282: https://www.ncbi.nlm.nih.gov/gene/285282
- Ensembl ENSG00000144840: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144840

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/rabl3.json