# RAD23B

Source: https://onco.cc/targets/rad23b/  
OnCo record `rad23b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RAD23B (Lysine-specific demethylase RAD23B) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas.

## Summary

Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Vorinostat.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RAD23 nucleotide excision repair protein B; Lysine-specific demethylase RAD23B; HHR23B; P58; HR23B
- Tags: cancer-genes-wave
- Symbol: RAD23B
- Class: enzyme
- Biology: Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Location: Nucleus; Cytoplasm (UniProt). Locus 9q31.2 (HGNC).
- Where found: Sarcomas: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9813: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9813
- UniProt P54727: https://www.uniprot.org/uniprotkb/P54727/entry
- NCBI Gene 5887: https://www.ncbi.nlm.nih.gov/gene/5887
- Ensembl ENSG00000119318: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119318

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/rad23b.json