# RADCOMP

Source: https://onco.cc/trials/radcomp/  
OnCo record `radcomp` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A randomised trial of protons versus photons for non-metastatic breast cancer, asking whether protons spare the heart and lung when the breast and nodes need radiation.

## Summary

RADCOMP (NCT02603341) randomises non-metastatic breast cancer to proton or photon radiotherapy, with major cardiovascular events as a long-horizon endpoint. The anatomy (left chest wall, internal mammary nodes, heart, lung) is where exit dose and a distal Bragg peak could matter. It tests integral dose and whether variable RBE at the chest-wall/heart interface helps or hurts. ClinicalTrials.gov listed the study as active, not recruiting, with primary completion estimated in 2036; no primary readout is in the corpus.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-17
- Tags: radiation-wave5
- Registry id: NCT02603341
- Phase: 3
- Setting: Non-metastatic breast cancer: proton versus photon radiotherapy
- Sponsor: Abramson Cancer Center at Penn Medicine

## Sources

- ClinicalTrials.gov NCT02603341: https://clinicaltrials.gov/study/NCT02603341

## Connected records

- cancers: [HER2-positive breast cancer](https://onco.cc/cancers/breast-her2-positive/), [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/), [Triple-negative breast cancer (TNBC)](https://onco.cc/cancers/tnbc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Proton therapy](https://onco.cc/technologies/proton-therapy/)
- terms: [Bragg peak](https://onco.cc/terms/bragg-peak/), [Linear energy transfer (LET)](https://onco.cc/terms/linear-energy-transfer/), [Relative biological effectiveness (RBE)](https://onco.cc/terms/relative-biological-effectiveness/)
- pairings: [Caution: proton therapy vs IMRT](https://onco.cc/pairings/proton-vs-imrt/)
- ideas: [Pooled coverage-with-evidence for proton therapy across all centres](https://onco.cc/ideas/idea-fund-proton-coverage-with-evidence/), [Use LET, RBE and alpha/beta to decide when protons beat IMRT](https://onco.cc/ideas/idea-bio2-let-rbe-ab-selects-protons/)

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JSON: https://onco.cc/api/v1/entities/radcomp.json