# RAP1A

Source: https://onco.cc/targets/rap1a/  
OnCo record `rap1a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RAP1A, member of RAS oncogene family; Ras-related protein Rap-1A; KREV-1; SMGP21
- Tags: cancer-genes-wave
- Symbol: RAP1A
- Class: enzyme
- Biology: Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signalling and its interaction with PKP3. Location: Cell membrane; Cytoplasm; Cytoplasm, perinuclear region; Cell junction (UniProt). Locus 1p13.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9855: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9855
- UniProt P62834: https://www.uniprot.org/uniprotkb/P62834/entry
- NCBI Gene 5906: https://www.ncbi.nlm.nih.gov/gene/5906
- Ensembl ENSG00000116473: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116473

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/rap1a.json