# RAP1GDS1

Source: https://onco.cc/targets/rap1gds1/  
OnCo record `rap1gds1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Oesophageal cancer, Breast cancer and 2 more.

## Summary

Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS.

Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.43, animal model 0.36, genetic association 0.34, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Renal Clear Cell Carcinoma, Oesophageal Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rap1 GTPase-GDP dissociation stimulator 1; SmgGDS
- Tags: cancer-genes-wave
- Symbol: RAP1GDS1
- Class: tumor-suppressor
- Biology: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake. Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Location: Cytoplasm, cytosol; Endoplasmic reticulum; Mitochondrion; Nucleus (UniProt). Locus 4q23 (HGNC).
- Where found: Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC); Oesophageal cancer: IntOGen driver in 1 cohort (ESCC); Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254); Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC); Oesophageal squamous cell carcinoma: IntOGen driver in 1 cohort (ESCC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9859: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9859
- UniProt P52306: https://www.uniprot.org/uniprotkb/P52306/entry
- NCBI Gene 5910: https://www.ncbi.nlm.nih.gov/gene/5910
- Ensembl ENSG00000138698: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138698

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Oesophageal squamous cell carcinoma](https://onco.cc/cancers/oesophageal-squamous-cell-carcinoma/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/rap1gds1.json