# RASA2

Source: https://onco.cc/targets/rasa2/  
OnCo record `rasa2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RASA2 (Ras GTPase-activating protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.

## Summary

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RAS p21 protein activator 2; Ras GTPase-activating protein 2; GAP1M
- Tags: cancer-genes-wave
- Symbol: RASA2
- Class: tumor-suppressor
- Biology: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). Location: Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 3q23 (HGNC).
- Where found: Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9872: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9872
- UniProt Q15283: https://www.uniprot.org/uniprotkb/Q15283/entry
- NCBI Gene 5922: https://www.ncbi.nlm.nih.gov/gene/5922
- Ensembl ENSG00000155903: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155903

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/rasa2.json