# RASSF6

Source: https://onco.cc/targets/rassf6/  
OnCo record `rassf6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RASSF6 (Ras association domain-containing protein 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.70).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Ras association domain family member 6; Ras association domain-containing protein 6
- Tags: cancer-genes-wave
- Symbol: RASSF6
- Class: other
- Biology: Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. Locus 4q13.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.53 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20796: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20796
- UniProt Q6ZTQ3: https://www.uniprot.org/uniprotkb/Q6ZTQ3/entry
- NCBI Gene 166824: https://www.ncbi.nlm.nih.gov/gene/166824
- Ensembl ENSG00000169435: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169435

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/rassf6.json