# RBBP7

Source: https://onco.cc/targets/rbbp7/  
OnCo record `rbbp7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RBBP7 (Histone-binding protein RBBP7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.76, genetic association 0.24).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RB binding protein 7, chromatin remodeling factor; Histone-binding protein RBBP7; RbAp46
- Tags: cancer-genes-wave
- Symbol: RBBP7
- Class: transcription
- Biology: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9890: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9890
- UniProt Q16576: https://www.uniprot.org/uniprotkb/Q16576/entry
- NCBI Gene 5931: https://www.ncbi.nlm.nih.gov/gene/5931
- Ensembl ENSG00000102054: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102054

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/rbbp7.json