# RBFOX1

Source: https://onco.cc/targets/rbfox1/  
OnCo record `rbfox1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RBFOX1 (RNA binding protein fox-1 homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.

## Summary

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.83, animal model 0.32, genetic association 0.66, somatic mutation 0.25). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RNA binding fox-1 homolog 1; RNA binding protein fox-1 homolog 1; A2BP1; FOX-1; HRNBP1
- Tags: cancer-genes-wave
- Symbol: RBFOX1
- Class: tumor-suppressor
- Biology: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Location: Nucleus; Cytoplasm (UniProt). Locus 16p13.3 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 1 cohort (PRAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18222: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18222
- UniProt Q9NWB1: https://www.uniprot.org/uniprotkb/Q9NWB1/entry
- NCBI Gene 54715: https://www.ncbi.nlm.nih.gov/gene/54715
- Ensembl ENSG00000078328: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078328

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/rbfox1.json