# RBM10

Source: https://onco.cc/targets/rbm10/  
OnCo record `rbm10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RBM10 (Ribosome biogenesis inhibitor MINAS-60) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and 4 more.

## Summary

Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus.

Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.00, somatic mutation 0.97). IntOGen calls it a driver in 16 cohorts (1 activating, 15 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Colorectal Adenocarcinoma, Lung Adenocarcinoma, Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RNA binding motif protein 10; Ribosome biogenesis inhibitor MINAS-60; DXS8237E; KIAA0122; GPATC9; ZRANB5; GPATCH9; S1-1
- Tags: cancer-genes-wave
- Symbol: RBM10
- Class: tumor-suppressor
- Biology: Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus. Location: Nucleus, nucleolus (UniProt). Locus Xp11.3 (HGNC).
- Where found: Lung cancer: Open Targets association 0.69 with lung cancer (MONDO_0008903); Pancreatic ductal adenocarcinoma: IntOGen driver in 4 cohorts (PAAD); Colorectal cancer: Open Targets association 0.60 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COADREAD); Bladder & urothelial cancer: Open Targets association 0.59 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 2 cohorts (BLCA); Biliary tract cancer: Open Targets association 0.58 with biliary tract cancer (MONDO_0003060); Non-small-cell lung cancer: Open Targets association 0.69 with non-small cell lung carcinoma (MONDO_0005233); IntOGen driver in 7 cohorts (LUAD, NSCLC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 15 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:9896: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9896
- UniProt P0DW28: https://www.uniprot.org/uniprotkb/P0DW28/entry
- NCBI Gene 8241: https://www.ncbi.nlm.nih.gov/gene/8241
- Ensembl ENSG00000182872: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182872

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Biliary tract cancer (all types)](https://onco.cc/cancers/biliary-tract-cancer/), [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/rbm10.json