# RCC2

Source: https://onco.cc/targets/rcc2/  
OnCo record `rcc2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RCC2 (regulator of chromosome condensation 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.94, animal model 0.28, genetic association 0.63, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: regulator of chromosome condensation 2; TD-60
- Tags: cancer-genes-wave
- Symbol: RCC2
- Class: other
- Biology: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organisation of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Location: Nucleus, nucleolus; Nucleus; Cytoplasm, cytoskeleton; Chromosome, centromere (UniProt). Locus 1p36.13 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30297: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30297
- UniProt Q9P258: https://www.uniprot.org/uniprotkb/Q9P258/entry
- NCBI Gene 55920: https://www.ncbi.nlm.nih.gov/gene/55920
- Ensembl ENSG00000179051: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179051

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/rcc2.json