# REC-4539

Source: https://onco.cc/drugs/rec-4539/  
OnCo record `rec-4539` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

REC-4539 is an experimental small molecule LSD1 inhibitor from Recursion Pharmaceuticals, in phase 1 trials for small-cell lung cancer, acute myeloid leukaemia and solid tumours.

## Summary

REC-4539 (EXS74539) is a small molecule LSD1 inhibitor from Recursion Pharmaceuticals. Described by the company as the first LSD1 inhibitor designed to be both reversible and CNS-penetrant. Its furthest stage is phase 1, for small-cell lung cancer, acute myeloid leukaemia and solid tumours. ClinicalTrials.gov registers it in one study linked below. Pipeline page: 'Status: Phase 1'. Registry NCT07517198 recruiting (sponsor Exscientia AI Ltd., a wholly owned subsidiary of Recursion). Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Also known as: EXS74539
- Tags: pipeline; ctgov-ingest
- Code: REC-4539
- Modality: Small molecule LSD1 inhibitor
- Mechanism: Described by the company as the first LSD1 inhibitor designed to be both reversible and CNS-penetrant.

## Sources

- Recursion Pharmaceuticals: recursion.com: https://www.recursion.com/pipeline
- Recursion Pharmaceuticals: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07517198
- ClinicalTrials.gov: trials of REC-4539: https://clinicaltrials.gov/search?intr=REC-4539

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- targets: [LSD1 (KDM1A)](https://onco.cc/targets/lsd1/)
- companies: [Recursion Pharmaceuticals](https://onco.cc/companies/recursion/)
- trials: [Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors](https://onco.cc/trials/nct07517198/)

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JSON: https://onco.cc/api/v1/entities/rec-4539.json