# RECIP 1.0 (PSMA PET response in prostate cancer)

Source: https://onco.cc/terms/recip-1/  
OnCo record `recip-1` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RECIP judges response on PSMA PET scans by the change in the total volume of PSMA-positive tumour and the appearance of new spots, and was built in men treated with lutetium-PSMA.

## Summary

Gafita and colleagues (Journal of Nuclear Medicine 2022) studied 124 men with metastatic castration-resistant prostate cancer treated with lutetium-177 PSMA who had PSMA PET at baseline and 12 weeks. RECIP 1.0 defines complete response as no PSMA uptake; partial response as a fall of 30% or more in PSMA-positive tumour volume without new lesions; progression as a rise of 20% or more with new lesions; and stable disease as anything else. Median survival was 8.3 months with RECIP progression against 13.1 months with stable disease. A composite with PSA (PSA + RECIP) is proposed as a trial endpoint.

## Fields

- Kind: Term
- Last checked: 2026-11-04
- Also known as: RECIP; RECIP 1.0; Response Evaluation Criteria in PSMA PET/CT; PSA + RECIP

## Sources

- Gafita et al., Novel framework for treatment response evaluation using PSMA PET/CT in patients with mCRPC (RECIP 1.0) (J Nucl Med 2022): https://doi.org/10.2967/jnumed.121.263072

## Connected records

- terms: [PCWG3 (Prostate Cancer Clinical Trials Working Group 3)](https://onco.cc/terms/pcwg3/), [PROMISE V2 and miTNM (PSMA PET staging framework)](https://onco.cc/terms/promise-mitnm/), [PSMA PET progression and response consensus (PPP)](https://onco.cc/terms/psma-pet-response-criteria/), [PSMA-RADS (PSMA PET reporting system)](https://onco.cc/terms/psma-rads/), [RECIST](https://onco.cc/terms/recist/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- technologies: [Lutetium-177 radioligand therapy](https://onco.cc/technologies/lu177-radioligand-therapy/), [PSMA PET](https://onco.cc/technologies/psma-pet/)

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