# RFX7

Source: https://onco.cc/targets/rfx7/  
OnCo record `rfx7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RFX7 (DNA-binding protein RFX7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Burkitt lymphoma.

## Summary

Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.66, animal model 0.32, genetic association 0.68).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: regulatory factor X7; DNA-binding protein RFX7; FLJ12994; RFXDC2
- Tags: cancer-genes-wave
- Symbol: RFX7
- Class: transcription
- Biology: Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity. May play a role in the process of ciliogenesis in the neural tube and neural tube closure. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315); Burkitt lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25777: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25777
- UniProt Q2KHR2: https://www.uniprot.org/uniprotkb/Q2KHR2/entry
- NCBI Gene 64864: https://www.ncbi.nlm.nih.gov/gene/64864
- Ensembl ENSG00000181827: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181827

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Burkitt lymphoma](https://onco.cc/cancers/burkitt-lymphoma/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/rfx7.json