# RGPD3

Source: https://onco.cc/targets/rgpd3/  
OnCo record `rgpd3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RGPD3 (RanBP2-like and GRIP domain-containing protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-small-cell lung cancer and Melanoma.

## Summary

UniProt has no function text for A6NKT7; HGNC names it "RANBP2 like and GRIP domain containing 3".

IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RANBP2 like and GRIP domain containing 3; RanBP2-like and GRIP domain-containing protein 3; RGP3
- Tags: cancer-genes-wave
- Symbol: RGPD3
- Class: tumor-suppressor
- Biology: UniProt has no function text for A6NKT7; HGNC names it "RANBP2 like and GRIP domain containing 3". Locus 2q12.2 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC); Melanoma: IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:32416: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32416
- UniProt A6NKT7: https://www.uniprot.org/uniprotkb/A6NKT7/entry
- NCBI Gene 653489: https://www.ncbi.nlm.nih.gov/gene/653489
- Ensembl ENSG00000153165: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153165

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/rgpd3.json