# RGS17

Source: https://onco.cc/targets/rgs17/  
OnCo record `rgs17` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RGS17 (Regulator of G protein signalling 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Regulates G protein-coupled receptor signalling cascades, including signalling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signalling activities.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: regulator of G protein signaling 17; Regulator of G protein signaling 17; RGSZ2; RGS-17
- Tags: cancer-genes-wave
- Symbol: RGS17
- Class: other
- Biology: Regulates G protein-coupled receptor signalling cascades, including signalling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signalling activities. Negatively regulates mu-opioid receptor-mediated activation of the G proteins. Location: Membrane; Synapse, synaptosome; Nucleus; Cytoplasm (UniProt). Locus 6q25.2 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14088: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14088
- UniProt Q9UGC6: https://www.uniprot.org/uniprotkb/Q9UGC6/entry
- NCBI Gene 26575: https://www.ncbi.nlm.nih.gov/gene/26575
- Ensembl ENSG00000091844: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091844

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/rgs17.json