# RHOBTB2

Source: https://onco.cc/targets/rhobtb2/  
OnCo record `rhobtb2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.67, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Rho related BTB domain containing 2; Rho-related BTB domain-containing protein 2; KIAA0717; DBC2
- Tags: cancer-genes-wave
- Symbol: RHOBTB2
- Class: enzyme
- Biology: Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. Locus 8p21.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18756: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18756
- UniProt Q9BYZ6: https://www.uniprot.org/uniprotkb/Q9BYZ6/entry
- NCBI Gene 23221: https://www.ncbi.nlm.nih.gov/gene/23221
- Ensembl ENSG00000008853: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000008853

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/rhobtb2.json