# RHPN2

Source: https://onco.cc/targets/rhpn2/  
OnCo record `rhpn2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RHPN2 (Rhophilin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer and Non-small-cell lung cancer.

## Summary

Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fibre formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.64, somatic mutation 0.78). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: rhophilin Rho GTPase binding protein 2; Rhophilin-2
- Tags: cancer-genes-wave
- Symbol: RHPN2
- Class: tumor-suppressor
- Biology: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fibre formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. Location: Cytoplasm, perinuclear region (UniProt). Locus 19q13.11 (HGNC).
- Where found: Breast cancer: IntOGen driver in 1 cohort (BRCA); Non-small-cell lung cancer: IntOGen driver in 2 cohorts (LUAD, LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19974: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19974
- UniProt Q8IUC4: https://www.uniprot.org/uniprotkb/Q8IUC4/entry
- NCBI Gene 85415: https://www.ncbi.nlm.nih.gov/gene/85415
- Ensembl ENSG00000131941: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131941

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/rhpn2.json