# RMI1

Source: https://onco.cc/targets/rmi1/  
OnCo record `rmi1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis.

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.44, affected pathway 0.87, genetic association 0.39).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RecQ mediated genome instability 1; RecQ-mediated genome instability protein 1; FLJ12888; BLAP75; C9orf76
- Tags: cancer-genes-wave
- Symbol: RMI1
- Class: other
- Biology: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. Location: Nucleus (UniProt). Locus 9q21.32 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25764: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25764
- UniProt Q9H9A7: https://www.uniprot.org/uniprotkb/Q9H9A7/entry
- NCBI Gene 80010: https://www.ncbi.nlm.nih.gov/gene/80010
- Ensembl ENSG00000178966: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178966

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/rmi1.json