# RMI2

Source: https://onco.cc/targets/rmi2/  
OnCo record `rmi2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.

## Summary

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM.

Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.87, genetic association 0.41, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RecQ mediated genome instability 2; RecQ-mediated genome instability protein 2; MGC24665; BLAP18; C16orf75
- Tags: cancer-genes-wave
- Symbol: RMI2
- Class: other
- Biology: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Location: Nucleus (UniProt). Locus 16p13.13 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903); Diffuse large B-cell lymphoma: Open Targets association 0.57 with diffuse large B-cell lymphoma (MONDO_0018905)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:28349: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28349
- UniProt Q96E14: https://www.uniprot.org/uniprotkb/Q96E14/entry
- NCBI Gene 116028: https://www.ncbi.nlm.nih.gov/gene/116028
- Ensembl ENSG00000175643: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175643

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/rmi2.json