# RNASET2

Source: https://onco.cc/targets/rnaset2/  
OnCo record `rnaset2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RNASET2 (Ribonuclease T2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.

## Summary

Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.70).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ribonuclease T2; Ribonuclease T2; RNASE6PL; FLJ10907; bA514O12.3
- Tags: cancer-genes-wave
- Symbol: RNASET2
- Class: enzyme
- Biology: Ribonuclease that plays an essential role in innate immune response by recognising and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. Location: Secreted; Lysosome lumen; Endoplasmic reticulum lumen; Mitochondrion intermembrane space (UniProt). Locus 6q27 (HGNC).
- Where found: Basal cell carcinoma: Open Targets association 0.53 with basal cell carcinoma (MONDO_0020804)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:21686: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21686
- UniProt O00584: https://www.uniprot.org/uniprotkb/O00584/entry
- NCBI Gene 8635: https://www.ncbi.nlm.nih.gov/gene/8635
- Ensembl ENSG00000026297: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000026297

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/)

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JSON: https://onco.cc/api/v1/entities/rnaset2.json