# RNF6

Source: https://onco.cc/targets/rnf6/  
OnCo record `rnf6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.

## Summary

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.08, somatic mutation 0.66, genetic literature 0.30). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ring finger protein 6; E3 ubiquitin-protein ligase RNF6; DKFZp686P0776
- Tags: cancer-genes-wave
- Symbol: RNF6
- Class: tumor-suppressor
- Biology: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Mediates polyubiquitination of QKI in macrophages, leading to its degradation. Location: Nucleus; Cytoplasm; Cell projection, axon; Nucleus, PML body (UniProt). Locus 13q12.13 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COADREAD); Oesophageal cancer: Open Targets association 0.51 with oesophageal cancer (MONDO_0007576)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10069: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10069
- UniProt Q9Y252: https://www.uniprot.org/uniprotkb/Q9Y252/entry
- NCBI Gene 6049: https://www.ncbi.nlm.nih.gov/gene/6049
- Ensembl ENSG00000127870: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127870

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/)

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JSON: https://onco.cc/api/v1/entities/rnf6.json