# ROBO4

Source: https://onco.cc/targets/robo4/  
OnCo record `robo4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ROBO4 (Roundabout homolog 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organisation and function.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Angiogenesis Inhibitor.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: roundabout guidance receptor 4; Roundabout homolog 4; FLJ20798; ECSM4
- Tags: cancer-genes-wave
- Symbol: ROBO4
- Class: other
- Biology: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organisation and function. Locus 11q24.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17985: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17985
- UniProt Q8WZ75: https://www.uniprot.org/uniprotkb/Q8WZ75/entry
- NCBI Gene 54538: https://www.ncbi.nlm.nih.gov/gene/54538
- Ensembl ENSG00000154133: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154133

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/robo4.json