# RON receptor (MST1R)

Source: https://onco.cc/targets/ron/  
OnCo record `ron` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RON is a receptor kinase from the same family as MET; multi-kinase drugs such as crizotinib and cabozantinib hit it as well as their main targets.

## Summary

Macrophage-stimulating protein receptor (RON, gene MST1R) is the sister receptor of MET, activated by MSP and overexpressed or aberrantly spliced in several carcinomas, where it promotes invasion and macrophage-driven inflammation. It is not a primary approval target, but crizotinib, cabozantinib and other MET-family inhibitors inhibit it and ChEMBL lists it among their targets.

## Fields

- Kind: Target
- Last checked: 2026-09-04
- Symbol: MST1R
- Class: kinase
- Biology: A receptor tyrosine kinase signalling through PI3K, MAPK and beta-catenin pathways; short isoforms act as constitutively active oncogenes.
- Where found: Overexpressed in subsets of breast, colon, pancreatic and lung carcinomas; Macrophages

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/MST1R
- UniProt Q04912: MST1R: https://www.uniprot.org/uniprotkb/Q04912/entry
- HGNC:7381 MST1R: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7381
- ChEMBL target CHEMBL2689: https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2689

## Connected records

- targets: [MET](https://onco.cc/targets/met/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [Cabozantinib](https://onco.cc/drugs/cabozantinib/), [Crizotinib](https://onco.cc/drugs/crizotinib/)

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JSON: https://onco.cc/api/v1/entities/ron.json