# RPL22

Source: https://onco.cc/targets/rpl22/  
OnCo record `rpl22` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RPL22 (Large ribosomal subunit protein eL22) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Colorectal cancer and Gastric & gastro-oesophageal junction cancer.

## Summary

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, somatic mutation 0.83, clinical 0.11). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Hepatocellular Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ribosomal protein L22; Large ribosomal subunit protein eL22; L22; eL22
- Tags: cancer-genes-wave
- Symbol: RPL22
- Class: tumor-suppressor
- Biology: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm (UniProt). Locus 1p36.31 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.53 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10315: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10315
- UniProt P35268: https://www.uniprot.org/uniprotkb/P35268/entry
- NCBI Gene 6146: https://www.ncbi.nlm.nih.gov/gene/6146
- Ensembl ENSG00000116251: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116251

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/rpl22.json