# RPS26

Source: https://onco.cc/targets/rps26/  
OnCo record `rps26` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.13, genetic association 0.27, genetic literature 0.76, clinical 0.11).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ribosomal protein S26; Small ribosomal subunit protein eS26; S26; eS26
- Tags: cancer-genes-wave
- Symbol: RPS26
- Class: other
- Biology: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 12q13.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10414: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10414
- UniProt P62854: https://www.uniprot.org/uniprotkb/P62854/entry
- NCBI Gene 6231: https://www.ncbi.nlm.nih.gov/gene/6231
- Ensembl ENSG00000197728: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197728

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/rps26.json