# RPS29

Source: https://onco.cc/targets/rps29/  
OnCo record `rps29` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RPS29 (Small ribosomal subunit protein uS14) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia and Myeloproliferative neoplasms.

## Summary

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.16, genetic association 0.31, clinical 0.11, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ribosomal protein S29; Small ribosomal subunit protein uS14; S29; uS14
- Tags: cancer-genes-wave
- Symbol: RPS29
- Class: other
- Biology: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 14q21.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.52 with myeloproliferative neoplasm (MONDO_0020076)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10419: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10419
- UniProt P62273: https://www.uniprot.org/uniprotkb/P62273/entry
- NCBI Gene 6235: https://www.ncbi.nlm.nih.gov/gene/6235
- Ensembl ENSG00000213741: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213741

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/rps29.json