# RPS6

Source: https://onco.cc/targets/rps6/  
OnCo record `rps6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RPS6 (Small ribosomal subunit protein eS6) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.

## Summary

Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Everolimus.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ribosomal protein S6; Small ribosomal subunit protein eS6; S6; eS6
- Tags: cancer-genes-wave
- Symbol: RPS6
- Class: other
- Biology: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 9p22.1 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10429: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10429
- UniProt P62753: https://www.uniprot.org/uniprotkb/P62753/entry
- NCBI Gene 6194: https://www.ncbi.nlm.nih.gov/gene/6194
- Ensembl ENSG00000137154: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137154

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/rps6.json