# RRM2B

Source: https://onco.cc/targets/rrm2b/  
OnCo record `rrm2b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RRM2B (Ribonucleoside-diphosphate reductase subunit M2 B) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma, Breast cancer and 5 more.

## Summary

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical centre required for catalysis.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, animal model 0.50, genetic association 0.07, clinical 0.99).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ribonucleotide reductase regulatory TP53 inducible subunit M2B; Ribonucleoside-diphosphate reductase subunit M2 B; p53R2
- Tags: cancer-genes-wave
- Symbol: RRM2B
- Class: enzyme
- Biology: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical centre required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. Location: Cytoplasm; Nucleus (UniProt). Locus 8q22.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908); Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903); Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170); Myeloproliferative neoplasms: Open Targets association 0.58 with myeloproliferative neoplasm (MONDO_0020076)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99; UniProt keyword "DNA repair". Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17296: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17296
- UniProt Q7LG56: https://www.uniprot.org/uniprotkb/Q7LG56/entry
- NCBI Gene 50484: https://www.ncbi.nlm.nih.gov/gene/50484
- Ensembl ENSG00000048392: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000048392

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/rrm2b.json