# RRN3

Source: https://onco.cc/targets/rrn3/  
OnCo record `rrn3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RRN3 (RNA polymerase I-specific transcription initiation factor RRN3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.

## Summary

Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RNA polymerase I transcription factor RRN3; RNA polymerase I-specific transcription initiation factor RRN3; DKFZp566E104; TIF-IA
- Tags: cancer-genes-wave
- Symbol: RRN3
- Class: oncogene
- Biology: Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). Location: Nucleus, nucleolus (UniProt). Locus 16p13.11 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30346: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30346
- UniProt Q9NYV6: https://www.uniprot.org/uniprotkb/Q9NYV6/entry
- NCBI Gene 54700: https://www.ncbi.nlm.nih.gov/gene/54700
- Ensembl ENSG00000085721: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085721

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/rrn3.json