# RUNX1T1

Source: https://onco.cc/targets/runx1t1/  
OnCo record `runx1t1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

RUNX1T1 (RUNX1 partner transcriptional co-repressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Leukaemia, Hepatocellular carcinoma and 5 more.

## Summary

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12.

Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, animal model 0.30, genetic association 0.32, somatic mutation 0.87). IntOGen calls it a driver in 7 cohorts (4 activating, 3 loss-of-function), covering Hepatocellular Carcinoma, Low-Grade Glioma, NOS, Lung Squamous Cell Carcinoma, Melanoma, Prostate Adenocarcinoma, Small Cell Lung Cancer.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: RUNX1 partner transcriptional co-repressor 1; MTG8; ZMYND2; AML1T1; CBFA2T1
- Tags: cancer-genes-wave
- Symbol: RUNX1T1
- Class: transcription
- Biology: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukaemic cells is involved in leukemogenesis and contributes to haematopoietic stem/progenitor cell self-renewal. Location: Nucleus (UniProt). Locus 8q21.3 (HGNC).
- Where found: Lung cancer: Open Targets association 0.58 with lung cancer (MONDO_0008903); Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Prostate cancer: IntOGen driver in 1 cohort (PRAD); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:1535: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1535
- UniProt Q06455: https://www.uniprot.org/uniprotkb/Q06455/entry
- NCBI Gene 862: https://www.ncbi.nlm.nih.gov/gene/862
- Ensembl ENSG00000079102: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079102

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/runx1t1.json