# SALL4

Source: https://onco.cc/targets/sall4/  
OnCo record `sall4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.

## Summary

Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells.

Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, animal model 0.29, genetic association 0.41, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: spalt like transcription factor 4; Sal-like protein 4; dJ1112F19.1; ZNF797
- Tags: cancer-genes-wave
- Symbol: SALL4
- Class: oncogene
- Biology: Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056); Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:15924: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15924
- UniProt Q9UJQ4: https://www.uniprot.org/uniprotkb/Q9UJQ4/entry
- NCBI Gene 57167: https://www.ncbi.nlm.nih.gov/gene/57167
- Ensembl ENSG00000101115: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101115

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/sall4.json