# SAMD9

Source: https://onco.cc/targets/samd9/  
OnCo record `samd9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.

## Summary

Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sterile alpha motif domain containing 9; Sterile alpha motif domain-containing protein 9; KIAA2004; FLJ20073; C7orf5
- Tags: cancer-genes-wave
- Symbol: SAMD9
- Class: other
- Biology: Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. Location: Cytoplasm (UniProt). Locus 7q21.2 (HGNC).
- Where found: Myelodysplastic syndromes / neoplasms: Open Targets association 0.66 with myelodysplastic syndrome (MONDO_0018881)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1348: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1348
- UniProt Q5K651: https://www.uniprot.org/uniprotkb/Q5K651/entry
- NCBI Gene 54809: https://www.ncbi.nlm.nih.gov/gene/54809
- Ensembl ENSG00000205413: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000205413

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)

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JSON: https://onco.cc/api/v1/entities/samd9.json