# SAMD9L

Source: https://onco.cc/targets/samd9l/  
OnCo record `samd9l` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SAMD9L (Sterile alpha motif domain-containing protein 9-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.

## Summary

May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.79, animal model 0.58, genetic association 0.19, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sterile alpha motif domain containing 9 like; Sterile alpha motif domain-containing protein 9-like; KIAA2005; FLJ39885; C7orf6
- Tags: cancer-genes-wave
- Symbol: SAMD9L
- Class: other
- Biology: May be involved in endosome fusion. Mediates down-regulation of growth factor signalling via internalisation of growth factor receptors. Location: Early endosome; Mitochondrion (UniProt). Locus 7q21.2 (HGNC).
- Where found: Myelodysplastic syndromes / neoplasms: Open Targets association 0.69 with myelodysplastic syndrome (MONDO_0018881)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1349: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1349
- UniProt Q8IVG5: https://www.uniprot.org/uniprotkb/Q8IVG5/entry
- NCBI Gene 219285: https://www.ncbi.nlm.nih.gov/gene/219285
- Ensembl ENSG00000177409: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177409

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)

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JSON: https://onco.cc/api/v1/entities/samd9l.json