# Samuraciclib

Source: https://onco.cc/drugs/samuraciclib/  
OnCo record `samuraciclib` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Samuraciclib is an oral cdk inhibitor from Pfizer, in registered phase 2 trials for metastatic cancer, HR-positive / HER2-negative breast cancer.

## Summary

Samuraciclib is listed on ClinicalTrials.gov as an intervention in 2 registered phase 2 trials sponsored by Pfizer and Hoffmann-La Roche, in metastatic cancer, HR-positive / HER2-negative breast cancer. A cyclin-dependent kinase inhibitor: the name stem -ciclib marks a small molecule that stops the cell-cycle kinases tumour cells rely on to divide. OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.

## Fields

- Kind: Treatment
- Status: phase-2
- Last checked: 2026-09-16
- Also known as: ICEC0942; CT7001
- Tags: pipeline; ctgov-ingest; registry-only
- Modality: Oral CDK inhibitor
- Mechanism: A cyclin-dependent kinase inhibitor: the name stem -ciclib marks a small molecule that stops the cell-cycle kinases tumour cells rely on to divide.

## Sources

- ClinicalTrials.gov: trials of Samuraciclib: https://clinicaltrials.gov/search?intr=Samuraciclib

## Connected records

- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- companies: [Flatiron Health (Roche)](https://onco.cc/companies/flatiron-health/), [Pfizer (incl. Seagen)](https://onco.cc/companies/pfizer/)
- trials: [A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer](https://onco.cc/trials/nct04802759/), [TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer. (Sub-Study C)](https://onco.cc/trials/nct06125522/)

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JSON: https://onco.cc/api/v1/entities/samuraciclib.json