# SCC-AFTER

Source: https://onco.cc/trials/scc-after/  
OnCo record `scc-after` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The trial testing a thing the NHS already does without evidence: giving radiotherapy after surgery for a high-risk squamous cell carcinoma, to stop it coming back.

## Summary

Adjuvant radiotherapy after excision of a high-risk cutaneous squamous cell carcinoma is widely offered in the UK and has never been tested in a randomised trial. SCC-AFTER, sponsored by Cardiff University with a target of 840 participants and a registered end date of 1 January 2031, is the trial. Together with SPOT-IT and EXCISE it makes Cardiff the centre of British keratinocyte cancer trials, which is itself worth noticing: the commonest cancers in the country have almost no randomised evidence base, and most of what is being built is being built in Wales.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: Adjuvant radiotherapy in patients with high-risk primary cutaneous Squamous Cell Carcinoma AFTER surgery; ISRCTN54806122
- Tags: uk; skin; radiotherapy; recruiting
- Registry id: ISRCTN54806122
- Phase: 3
- Setting: Open-label multicentre two-arm phase 3 randomised trial of adjuvant radiotherapy against no adjuvant radiotherapy after surgery for high-risk primary cutaneous squamous cell carcinoma; registered end date 1 January 2031
- Sponsor: Cardiff University
- Enrolled: 840

## Sources

- ISRCTN54806122: https://www.isrctn.com/ISRCTN54806122

## Connected records

- cancers: [Cutaneous squamous cell carcinoma](https://onco.cc/cancers/cutaneous-scc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)
- institutions: [Velindre Cancer Centre](https://onco.cc/institutions/velindre-cardiff/)

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JSON: https://onco.cc/api/v1/entities/scc-after.json