# SCN10A

Source: https://onco.cc/targets/scn10a/  
OnCo record `scn10a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SCN10A (Sodium channel protein type 10 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.00, clinical 0.86).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sodium voltage-gated channel alpha subunit 10; Sodium channel protein type 10 subunit alpha; Nav1.8; hPN3; PN3
- Tags: cancer-genes-wave
- Symbol: SCN10A
- Class: other
- Biology: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Location: Cell membrane (UniProt). Locus 3p22.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10582: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10582
- UniProt Q9Y5Y9: https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry
- NCBI Gene 6336: https://www.ncbi.nlm.nih.gov/gene/6336
- Ensembl ENSG00000185313: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185313

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/scn10a.json