# SCN2A

Source: https://onco.cc/targets/scn2a/  
OnCo record `scn2a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SCN2A (Sodium channel protein type 2 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.41, genetic association 0.21, clinical 0.86).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sodium voltage-gated channel alpha subunit 2; Sodium channel protein type 2 subunit alpha; Nav1.2; HBSCII; HBSCI; SCN2A1; SCN2A2
- Tags: cancer-genes-wave
- Symbol: SCN2A
- Class: other
- Biology: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Location: Cell membrane (UniProt). Locus 2q24.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10588: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10588
- UniProt Q99250: https://www.uniprot.org/uniprotkb/Q99250/entry
- NCBI Gene 6326: https://www.ncbi.nlm.nih.gov/gene/6326
- Ensembl ENSG00000136531: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136531

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/scn2a.json