# SDC4

Source: https://onco.cc/targets/sdc4/  
OnCo record `sdc4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.

## Summary

Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.

Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes clinical 0.89, literature 0.94, genetic association 0.00, somatic mutation 0.93, animal model 0.54).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: syndecan 4; Syndecan-4; SYND4; amphiglycan; ryudocan
- Tags: cancer-genes-wave
- Symbol: SDC4
- Class: other
- Biology: Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Location: Membrane; Secreted (UniProt). Locus 20q13.12 (HGNC).
- Where found: Lung cancer: Open Targets association 0.67 with lung cancer (MONDO_0008903); Non-small-cell lung cancer: Open Targets association 0.66 with non-small cell lung carcinoma (MONDO_0005233)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.89. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10661: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10661
- UniProt P31431: https://www.uniprot.org/uniprotkb/P31431/entry
- NCBI Gene 6385: https://www.ncbi.nlm.nih.gov/gene/6385
- Ensembl ENSG00000124145: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124145

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/sdc4.json