# SDCBP

Source: https://onco.cc/targets/sdcbp/  
OnCo record `sdcbp` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SDCBP (Syntenin-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.

## Summary

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signalling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalisation and degradation of TGFR1.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: syndecan binding protein; Syntenin-1; MDA-9; SDCBP1
- Tags: cancer-genes-wave
- Symbol: SDCBP
- Class: tumor-suppressor
- Biology: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signalling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalisation and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signalling components. Location: Cell junction, focal adhesion; Cell junction, adherens junction; Cell membrane; Endoplasmic reticulum membrane (UniProt). Locus 8q12.1 (HGNC).
- Where found: Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10662: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10662
- UniProt O00560: https://www.uniprot.org/uniprotkb/O00560/entry
- NCBI Gene 6386: https://www.ncbi.nlm.nih.gov/gene/6386
- Ensembl ENSG00000137575: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137575

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/)

---
JSON: https://onco.cc/api/v1/entities/sdcbp.json