# SDCCAG8

Source: https://onco.cc/targets/sdccag8/  
OnCo record `sdccag8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.

## Summary

Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.68, animal model 0.44, genetic association 0.70).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: SHH signaling and ciliogenesis regulator SDCCAG8; Serologically defined colon cancer antigen 8; NY-CO-8; CCCAP; SLSN7; NPHP10; BBS16
- Tags: cancer-genes-wave
- Symbol: SDCCAG8
- Class: other
- Biology: Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body; Cell junction (UniProt). Locus 1q43-q44 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.53 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:10671: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10671
- UniProt Q86SQ7: https://www.uniprot.org/uniprotkb/Q86SQ7/entry
- NCBI Gene 10806: https://www.ncbi.nlm.nih.gov/gene/10806
- Ensembl ENSG00000054282: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000054282

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

---
JSON: https://onco.cc/api/v1/entities/sdccag8.json